Hadi Alizadeh | Cancer stem cells | Best Researcher Award

Published on by Global Academic Awards

Mr. Hadi Alizadeh | Cancer stem cells | Best Researcher Award

Graduate Master Student, Tarbiat Modares University, Iran

Mr. Hadi Alizadeh is a Master’s graduate in Molecular Genetics from Tarbiat Modares University, Tehran, with a thesis on AGPAT3 gene and cisplatin resistance in ovarian cancer cells. His research encompasses gene expression analysis, drug discovery, and epigenomic profiling, focusing on chemoresistance mechanisms in cancer. He has contributed to various publications and presented at international conferences. Skilled in PCR, RNA-seq, flow cytometry, and bioinformatics, he is proficient in machine learning and molecular dynamics. Hadi has been recognized for his academic excellence, ranking highly in national exams. He also has hands-on experience in medical genetics and as a teaching assistant. 🧬💉🔬

 

Publication Profile

Orcid

Education

Mr. Hadi Alizadeh completed his Master’s in Molecular Genetics at Tarbiat Modares University, Tehran, from October 2021 to November 2023, achieving an impressive average of 18.2/20. His thesis, titled “Introduction of AGPAT3 gene as a regulator of cisplatin resistance in A2780 ovarian cancer cell line,” was supervised by Dr. Soltani. Prior to this, he earned a Bachelor’s degree in Genetics from Islamic Azad University, North Tehran, from October 2016 to May 2020, with a strong academic performance, securing an average of 17.83/20. His solid educational background highlights his commitment to molecular genetics and cancer research. 📚🧬

 

Research Experience

Mr. Hadi Alizadeh’s research experience includes significant work in molecular genetics and cancer research. For his Master’s thesis, he explored AGPAT3 gene as a regulator of cisplatin resistance in ovarian cancer cells, performing RNA-seq and various functional assays like RT-qPCR, western blotting, and apoptosis assays, revealing AGPAT3’s role in survival and cell cycle arrest under cisplatin treatment. He also studied the synergistic effect of dendrosomal nano-curcumin (DNC) with cisplatin in reducing cisplatin resistance. Additionally, he worked on epigenomic profiling of oxaliplatin-resistant HCT116 colorectal cancer cells and drug discovery targeting mTORC1 signaling. 🧬💻

 

Honors & Awards 🏆🎓

Mr. Hadi Alizadeh has demonstrated exceptional academic achievements throughout his career. In 2021, he ranked 18th out of nearly 10,000 participants in the national entrance exam for medical genetics in the healthcare system, showcasing his expertise and dedication. Additionally, he secured the 25th position among approximately 7,000 candidates in the national entrance exam for a Master’s program in genetics. These prestigious rankings highlight his strong academic foundation and passion for genetics research, setting the stage for his future contributions to the field. 🌟📚

 

Professional Experience 💼🔬

Mr. Hadi Alizadeh has gained valuable hands-on experience in various research and clinical settings. As a volunteer at Imam Khomeini Hospital in Tehran, he collected samples and performed RNA extraction for various projects. In his role as an apprentice at the Cytogenetic Lab, he conducted karyotyping as part of clinical genetic analyses, gaining key insights into genetic disorders. Additionally, as a Genetic Laboratory Technician prior to his Master’s, Mr. Alizadeh contributed to the COVID-19 response by performing RNA extraction and real-time PCR on samples, further honing his technical expertise in molecular genetics. 🧬🔬

 

Research Focus

Mr. Hadi Alizadeh’s research primarily focuses on molecular genetics and cancer biology. His work explores the mechanisms of chemoresistance in cancer, particularly involving the mTORC1 signaling pathway and its role in platinum-based chemotherapy resistance. He also investigates the epigenomic and transcriptomic changes related to chemoresistance in colorectal cancer cells. His expertise extends to drug discovery, with a focus on molecular dynamics and virtual screening for targeting cancer resistance mechanisms. Alizadeh’s research contributes significantly to understanding cancer cell survival and potential therapeutic strategies. 🧬💉💡

 

Publication Top Notes

  • Introduction of AGPAT3 gene as a regulator of cisplatin resistance in A2780 ovarian cancer
    cell line (under review after revision in PLOS ONE)
  •  Phosphatidic acid as a cofactor of mTORC1 in platinum-based chemoresistance: Mechanisms
    and therapeutic potential (Review article) (Published)
  •  Epigenomic and Transcriptomic Profiling of Oxaliplatin Resistant HCT116 Colorectal
    Cancer Cells Reveals Super-Enhancer-Driven Mechanisms of Chemoresistance
    (Bioinformatic article) (Revision in Scientific Reports)
  • Comparison of Machine Learning Algorithms and Feature Selection Methods for Identifying
    Important Features of Expression Data (Manuscript preparation)
  • Bioinformatic Analysis to find drugs Inhibiting mTORC1 as a Phosphatidic AcidDisplacement Strategy (Manuscript preparation)
  •  Comparison of Signaling Pathways and Genetic Modifications of Cancer Stem Cells with
    Normal Stem Cells (Review article) (ready to submit)

 

 

 

Lan Hong | Stem cell Therapy | Best Researcher Award

Published on by Global Academic Awards

Prof. Lan Hong | Stem cell Therapy | Best Researcher Award

Prof. Lan Hong, Department of Physiology and Pathophysiology College of Medicine, Yanbian University, China

Prof. Lan Hong is a distinguished professor and doctoral supervisor at Yanbian University, China, specializing in physiology and pathophysiology. With a Ph.D. in Physiology from Yanbian University, her research focuses on myocardial infarction, cardiac endocrine hormones, and stem cell therapy for heart regeneration. Prof. Hong has held prominent roles at Texas A&M University and led several significant research projects funded by the National Natural Science Foundation of China. She is an active member of various scientific societies, including the Chinese Physiological Society. Her research aims to uncover novel mechanisms for cardiovascular protection and regeneration. 🌟🫀

Publication Profile

Google Scholar

Education 🎓

Prof. Lan Hong completed his educational journey at Yanbian University School of Medicine, Yanji, China. He earned his Ph.D. in Physiology and Pathophysiology (2009-2012), following a Master’s degree in the same field (2006-2009). His foundational studies were rooted in Clinical Medicine, culminating in a Bachelor’s degree (2001-2006). Prof. Hong’s extensive academic background laid the groundwork for his pioneering research in cardiovascular health, particularly in myocardial infarction, cardiac regeneration, and stem cell therapies. His educational achievements reflect his deep commitment to advancing medical science and physiology. 📚💉

 

Professional Experience 💼

Prof. Lan Hong is currently a Professor at the Yanbian University School of Medicine (2024–Present) in the Department of Physiology and Pathophysiology. Previously, he served as an Associate Professor at the same institution (2019–2023). Prof. Hong has also made significant contributions to regenerative medicine during his time in the Biomedical Institute for Regenerative Research (BIRR) at Texas A&M University – Commerce, Texas, where he worked as a Research Assistant (2019), Research Assistant Professor (2017–2018), and Postdoctoral Research Associate (2017). His earlier academic role included an Instructor position at Yanbian University (2013–2017). 🌍🔬

 

Research Support 🔬💡

Prof. Lan Hong has led numerous groundbreaking research projects as a Principal Investigator. Currently, he is investigating how LncRNA-CIR can repair infarcted hearts by inducing MSCs into cardiomyocytes through CDK1, supported by the National Natural Science Foundation of China (2024–2027). His prior work includes exploring ANP’s cardioprotective effects against ischemia/reperfusion injury (2018–2021), as well as preclinical studies on induced pluripotent stem cell therapy for myocardial infarction (2021–2024). Prof. Hong has also led projects on Ginseng’s effects on myocardial protection and Schisandrin B‘s impact on ischemic injury, further advancing cardiovascular research. ❤️🧬

 

Research Focus Areas 🔬❤️

Prof. Lan Hong’s research spans multiple facets of cardiovascular physiology, cell signaling, and pharmacology. His work primarily investigates the secretion of atrial natriuretic peptide (ANP) in response to hypoxic conditions and various pharmacological agents. His studies explore pathways like MAPK, PI3K, and HIF-1α, which regulate cardiac function and response to injury. Additionally, Prof. Hong has contributed significantly to antimicrobial drug development, particularly against methicillin-resistant Staphylococcus aureus (MRSA) and other resistant pathogens. His research also delves into mitochondrial stress, cell signaling pathways, and pharmacological interventions for myocardial protection. 💉🧬⚡

 

Publication Top Notes

  • Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against MRSA and QRSA – European Journal of Medicinal Chemistry, 2013 (57 citations) 🦠
  • MAPK and PI3K pathways regulate hypoxia-induced atrial natriuretic peptide secretion – Biochemical and Biophysical Research Communications, 2013 (38 citations) 💓
  • Atrial natriuretic peptide prevents mitochondrial permeability transition pore opening – European Journal of Pharmacology, 2012 (37 citations) 🔬
  • Synthesis and biological evaluation of 5-aryloxypyrazole derivatives as potential antimicrobial agents – Bioorganic & Medicinal Chemistry Letters, 2012 (35 citations) 💊
  • Synthesis and positive inotropic activity of quinolin-7-yl derivatives – Bioorganic & Medicinal Chemistry Letters, 2008 (26 citations) 💥
  • Adenosine A2 receptor activation ameliorates mitochondrial oxidative stress – Free Radical Biology and Medicine, 2017 (22 citations) ⚡
  • Ethanol attenuates sensory responses in cerebellar granule cells – Neuroscience Letters, 2014 (19 citations) 🍷
  • Ouabain stimulates atrial natriuretic peptide secretion via endothelin-1/ETB receptor – Life Sciences, 2012 (16 citations) 💧
  • Cathepsins in the extracellular space: Focusing on non-lysosomal proteolytic functions – Cellular Signaling, 2023 (13 citations) 🔬
  • Endogenous ET-1 promotes ANP secretion in hypoxic beating rat atria – Peptides, 2019 (12 citations) 🌱