Angélique Nicolas Messi | Organic Chemistry | Best Researcher Award

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Dr. Angélique Nicolas Messi | Organic Chemistry | Best Researcher Award

University of Yaoundé 1 | Cameroon

Dr. Angélique Nicolas Messi is a researcher specializing in pharmaceutical and natural products chemistry, with a focus on discovering bioactive compounds from medicinal plants. Her work emphasizes neuroprotection, anticancer, antimalarial, anti-HIV/AIDS, and anti-neuroinflammatory activities, targeting both natural and synthetic compounds. She employs bioguided isolation, synthesis of flavonoids and biflavonoids, and advanced spectroscopic techniques (1D and 2D NMR) for drug discovery and chemotaxonomy. Dr. Angélique Nicolas Messi has published 11 papers, cited over 70 times, with an h-index of 4, covering topics such as antileishmanial agents from Tarenna conferta, HIV-1 inhibitors from Ochna rhizomatosa, and plant-derived alkaloids for leukemia and malaria drug development, highlighting her contribution to understanding the pharmacological potential of African flora.

Profile: Scopus | Google Scholar

Featured Publications

  • Ndongo, J. T., Issa, M. E., Messi, A. N., Ngo Mbing, J., Cuendet, M., & Pegnyemb, D. E., et al. (2015). Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana. Natural Product Research, 29(17), 1684–1687.

  • Messi, A. N., Mbing, J. N., Ndongo, J. T., Nyegue, M. A., Tchinda, A. T., & Yemeda, F. L., et al. (2016). Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities. Phytochemistry Letters, 17, 119–125.

  • Djova, S. V., Nyegue, M. A., Messi, A. N., Afagnigni, A. D., & Etoa, F. X. (2019). Phytochemical study of aqueous extract of Ochna schweinfurthiana F. Hoffm powder bark and evaluation of their anti-inflammatory, cytotoxic, and genotoxic activities. Evidence-Based Complementary and Alternative Medicine, 2019, 8908343.

  • Messi, A. N., Bonnet, S. L., Owona, B. A., Wilhelm, A., Kamto, E. L. D., & Ndongo, J. T., et al. (2022). In vitro and in silico potential inhibitory effects of new biflavonoids from Ochna rhizomatosa on HIV-1 integrase and Plasmodium falciparum. Pharmaceutics, 14(8), 1701.

  • Nyegue, M. A., Mbing, J. N., Djova, S. V., Messi, A. N., Olugu, S. V., & Pegnyemb, D. E., et al. (2016). Evaluation of the antioxidant activity of the leaves, stem-barks extracts and fractions of Ochna schweinfurthiana F. Hoffm (Ochnaceae). African Journal of Pharmacy and Pharmacology, 10(17), 370–378.

Irem kulu | Organic Chemistry | Best Researcher Award

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Assoc Prof Dr. Irem kulu | Organic Chemistry | Best Researcher Award

Assoc Prof Dr. Irem kulu, Gebze Technical University, Turkey

Assoc. Prof. Dr. İrem Kulu is an accomplished organic chemist with a PhD from Yıldız Technical University, Turkey. Her expertise lies in C-C and C-N bond formation reactions of cyclic systems. With a diverse background including roles at Novartis and UMASS Amherst, she’s currently an Associate Professor at Gebze Technical University. Her research spans various projects, notably focusing on drug synthesis and bioorthogonal nanozymes. As a project coordinator and researcher, she contributes significantly to TÜBİTAK-funded initiatives. 🧪🔬 Passionate about synthesizing novel compounds, her work holds promise for advancing medicinal chemistry.

Publication Profile:

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Education:

Dr. İrem Kulu is a dedicated scholar in organic chemistry, graduating from Yıldız Technical University in Turkey. She completed her Bachelor of Science, Master of Science, and PhD degrees from the Department of Organic Chemistry at the same institution. Her research journey began with her Bachelor’s thesis focusing on the synthesis of organic compounds. In her Master’s thesis, she explored Domino Heck type Hydroarylation reactions and new isoindolines. For her doctoral work, she delved into C-C and C-N bond formation reactions of cyclic systems. Under the guidance of Prof. Dr. Zehra Nüket Öcal Sunguroğlu, she demonstrated a keen interest in advancing organic synthesis. 🎓🔬

 

Experience :

Dr. İrem Kulu’s career spans diverse roles in academia and industry, showcasing her expertise in organic chemistry. She began as a post-doctoral researcher at Gebze Technical University, contributing to TÜBİTAK projects focused on hybrid materials synthesis. Transitioning to industry, she served as a Synthesis Chemist at Novartis, specializing in API synthesis. Her academic journey continued as an Assistant Professor at Gebze Technical University, where she eventually ascended to Associate Professor. Notably, she pursued post-doctoral research at UMASS Amherst, delving into bioorthogonal nanozymes. Her multifaceted experience reflects a commitment to advancing chemical science across academia and industry. 🔬👩‍🔬

Research Focus:

Dr. İrem Kulu’s research primarily focuses on organic synthesis and medicinal chemistry, as evidenced by her extensive publication record. She has contributed significantly to the development of novel compounds with potential pharmacological applications, including antidepressants, antimicrobials, and anticancer agents. Her work spans various synthetic methodologies, such as Domino-Heck reactions, reductive Heck reactions, and [3+2] cycloadditions, aiming to create diverse molecular architectures. Additionally, she explores the physicochemical properties and biological activities of synthesized compounds, particularly their interactions with metal ions and their potential as photosensitizers. Dr. Kulu’s research embodies a quest for innovative solutions in drug discovery and development. 💊🔬

Publication Top Notes:

  1. Domino‐Heck Reactions of Carba‐ and Oxabicyclic, Unsaturated Dicarboximides: Synthesis of Aryl‐Substituted, Bridged Perhydroisoindole Derivatives 📚 Cited by: 25 🗓️ Year: 2009
  2. The synthesis of epiboxidine and related analogues as potential pharmacological agents 📚 Cited by: 20 🗓️ Year: 2011
  3. A multidisciplinary approach to coronavirus disease (COVID-19) 📚 Cited by: 16 🗓️ Year: 2021
  4. Effects of metal ion in cationic Pd (II) and Ni (II) phthalocyanines on physicochemical and photodynamic inactivation properties📚 Cited by: 15 🗓️ Year: 2022
  5. Design, synthesis and biological evaluation of 8-aminoquinoline-1, 2, 3-triazole hybrid derivatives as potential antimicrobial agents📚 Cited by: 14 🗓️ Year: 2022
  6. Reductive Heck Reactions and [3+ 2] Cycloadditions of Unsaturated N, N’-Bistricyclic Imides
  7. Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemic Linaria corifolia Desf. (Plantaginaceae)
  8. Synthesis of arylated norbornyl amino acid esters
  9. Hybrid materials based on pyrene-substituted metallo phthalocyanines as sensing layers for ammonia detection: Effect of the number of pyrene substituents
  10. Photodynamic Inactivation of Antibiotic-Resistant and Sensitive Aeromonas hydrophila with Peripheral Pd(II)- vs. Zn(II)-Phthalocyanines