Assoc. Prof. Dr. Yanlian Chen, Sun Yat-sen University, China
Dr. Yanlian Chen is an Associate Professor at The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. She earned her Ph.D. in Cell Biology and B.Sc. in Biotechnology from Sun Yat-sen University. Dr. Chen’s research advances understanding of vascular calcification, cancer immunotherapy, telomere biology, and viral infection control. She has led multiple national and provincial research projects and holds several patents. Her work is widely published in prestigious journals like Cancer Immunology Research and Signal Transduction and Targeted Therapy. She is an active member of leading medical associations, contributing significantly to vascular and hypertension research. 🌟
Publication Profile
Scopus
Education 📚
Yanlian Chen completed her Bachelor of Science in Biotechnology (2009-2013) and Ph.D. in Cell Biology (2013-2018) at the School of Life Sciences, Sun Yat-sen University, China. During her academic training, she gained extensive expertise in molecular biology, cellular signaling pathways, and translational medicine. Her doctoral research provided deep insights into telomere maintenance and RNA-binding proteins, laying a strong foundation for her future work on vascular calcification and immune modulation. Her comprehensive education enabled her to develop a multidisciplinary approach, bridging molecular mechanisms with clinical applications in vascular disease and cancer biology. 🎓
Experience 🧪
Dr. Chen began her academic career as a Postdoctoral Fellow at Sun Yat-sen University (2018-2021), where she studied tumor DNA damage tolerance. She then progressed to Assistant Researcher (2021-2024) and now serves as Associate Researcher (2024–present) at The Eighth Affiliated Hospital of Sun Yat-sen University. Throughout her career, she has spearheaded numerous high-impact research projects, managed interdisciplinary collaborations, and contributed to innovations in vascular health and cancer immunotherapy. Her clinical translational focus blends fundamental cell biology with therapeutic intervention strategies, leading to both significant publications and multiple patents. 🔬
Awards and Honors 🏆
Dr. Chen has been recognized for her excellence in research with prestigious awards, including the Third Prize of the Chinese Medical Science and Technology Award by the Chinese Medical Association in 2023 and the First Prize from the Guangdong Medical Association the same year. These honors reflect her pioneering work in understanding and intervening in hypertension-induced vascular injury. Additionally, she holds important professional roles, such as Standing Committee Member positions in the Pan-Vascular Disease Professional Committee and the Hypertension Branch of Guangdong Precision Medicine Application Society. Her accolades highlight her leadership and innovation in biomedical research. 🥇
Research Focus 🔬
Dr. Chen’s research focuses on the molecular mechanisms regulating vascular calcification, cancer immunotherapy targeting PD-L1 pathways, telomere stability, and anti-viral strategies against SARS-CoV-2. Her work integrates cellular biology with translational medicine, particularly investigating the roles of SIRT1 ubiquitination, MOV10/TERRA axis, and Let-7 microRNA pathways. She also explores therapeutic interventions for vascular aging and damage through metabolic modulation and immune checkpoint inhibitors. Her studies are aimed at developing novel clinical treatments for cardiovascular diseases and cancer, bridging laboratory discoveries with real-world health applications. Her research is cutting-edge and highly impactful. ⚡
Publication Top Notes
The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair